Question 1

What is the starting dose of sermorelin?

Accepted Answer

Common adult research-context starting guidance is 100-200 mcg subQ at bedtime for the first 1-2 weeks, then titrating to 200-300 mcg nightly. The historical FDA-era pediatric label used 0.2-0.3 mg/day. Adult protocols are typically adjusted based on response, sleep changes, and IGF-1 lab trends. This is not a dosing recommendation - work with a licensed clinician.

Question 2

How much BAC water do you use to reconstitute a 10 mg sermorelin vial?

Accepted Answer

A common research-context setup is 3 mL of bacteriostatic water in a 10 mg vial, which gives a 3,333 mcg/mL concentration. On a U-100 insulin syringe, that produces clean whole-unit doses: 100 mcg = 3 units, 200 mcg = 6 units, 300 mcg = 9 units. For other vial sizes or water volumes, recheck with the PepPal calculator .

Question 3

How many units of sermorelin should I inject?

Accepted Answer

It depends on your vial size and how much BAC water you used. With the common 10 mg vial plus 3 mL BAC water setup, 200 mcg equals 6 units on a U-100 syringe and 300 mcg equals 9 units. For any other setup, use the calculator linked in this protocol to get the exact unit count.

Question 4

What is sermorelin's half-life?

Accepted Answer

Sermorelin's plasma half-life is approximately 11-12 minutes after either IV or subQ injection, per Ishida et al. (2020) and the FDA-era prescribing data. Plasma clearance is in the 2.4-2.8 L/min range. The growth hormone pulse triggered by sermorelin lasts longer than the parent peptide stays in circulation.

Question 5

Is sermorelin FDA-approved in 2026?

Accepted Answer

Sermorelin was FDA-approved in 1990 (diagnostic use) and 1997 (pediatric GH deficiency, brand name Geref). Serono Laboratories voluntarily discontinued Geref in 2008 due to manufacturing difficulties, not safety concerns. As of June 2026, there is no currently marketed FDA-approved sermorelin product. However, sermorelin still sits in FDA 503A Category 1, which means licensed compounding pharmacies can legally prepare it with a prescription.

Question 6

Is sermorelin legal to compound in 2026?

Accepted Answer

Yes. Sermorelin remains in FDA 503A Category 1, which means licensed 503A and 503B compounding pharmacies can legally prepare it for patients with a valid prescription. This is different from most other research peptides (BPC-157, CJC-1295, ipamorelin, TB-500, and others), which sit in Category 2 and cannot be legally compounded.

Question 7

What are the most common observed effects of sermorelin?

Accepted Answer

Across 350 FDA-era trial patients, the most common observed effect was a mild injection-site reaction - pain, swelling, or redness - in about 1 in 6 participants. Only 3 of 350 patients discontinued because of it. Less common effects (each under 1%) included headache, flushing, dizziness, difficulty swallowing, drowsiness, and hives. About 6.5% developed hypothyroidism during trials, which is why thyroid labs are standard monitoring.

Question 8

What results can be expected from sermorelin?

Accepted Answer

Practitioner timelines and FDA-era data line up on a similar pattern: sleep and recovery changes often appear in 2-4 weeks. Body-composition shifts and IGF-1 increases usually need 3-6 months of consistent nightly dosing. Adult-population endpoint data outside practitioner literature is limited, so individual response varies.

Question 9

How does sermorelin compare to tesamorelin and CJC-1295?

Accepted Answer

All three target the GHRH receptor, but they differ in half-life, dosing, and regulatory status. Sermorelin: ~12 minute half-life, nightly, 503A Category 1. Tesamorelin: ~26-38 minute half-life, daily, FDA-approved for HIV-associated lipodystrophy. CJC-1295 (DAC): ~6-8 day half-life, weekly, 503A Category 2 (cannot be legally compounded). See the Tesamorelin protocol and CJC-1295 (DAC) protocol for full details.

Question 10

Should sermorelin be taken at night?

Accepted Answer

Most research-context protocols use sermorelin 30-60 minutes before bed on an empty stomach. The body's biggest natural growth hormone pulse happens during early sleep, and bedtime dosing rides along with that pulse. Eating raises insulin, which blunts the GH response, so most protocols wait 60-90 minutes after the last meal before injecting.

Question 11

What vial sizes does sermorelin come in?

Accepted Answer

Common research-channel sermorelin vial sizes include 2 mg, 5 mg, 9 mg, 10 mg, and 15 mg lyophilized formats. The 10 mg vial is widely available from current compounded and research suppliers. Smaller vials (2 mg, 5 mg) give the cleanest whole-unit syringe math. Larger vials last longer once reconstituted - but remember the 28-day reconstituted-solution shelf life.

Question 12

How should reconstituted sermorelin be stored?

Accepted Answer

Store reconstituted sermorelin upright in the refrigerator at 2-8°C (36-46°F), protect from light, and use within 28 days. Do not freeze reconstituted sermorelin. Discard if the solution is cloudy, discolored, or has any visible particles. Brief room-temperature windows (such as travel) are usually fine, but get it back into refrigeration as soon as possible.

Question 13

Can sermorelin be stacked with ipamorelin?

Accepted Answer

Community protocols often discuss pairing sermorelin (a GHRH analogue) with ipamorelin (a GH secretagogue/GHRP) at bedtime to recruit both signaling pathways. Direct stack-specific clinical trial evidence is limited, and adding compounds increases the safety and quality-control surface area. Read the PepPal Peptide Stacking 101 guide before combining compounds.

Question 14

Is this page medical advice?

Accepted Answer

No. This is an educational research reference. It summarizes published FDA-era data, pharmacokinetic literature, and practitioner-derived protocol structures so you have a clear starting point for a conversation with a licensed clinician. It is not a treatment plan and does not replace medical guidance.

Phase	Daily reference amount	Units / volume
Weeks 1–2	200 µg	12 units (0.12 mL)
Weeks 3–4	300 µg	18 units (0.18 mL)
Weeks 5–6	400 µg	24 units (0.24 mL)
Weeks 7–8	500 µg	30 units (0.30 mL)

Phase	5 mg 3 mL water	10 mg 3 mL water
Weeks 1–2	12 u 0.12 mL	6 u 0.06 mL
Weeks 3–4	18 u 0.18 mL	9 u 0.09 mL
Weeks 5–6	24 u 0.24 mL	12 u 0.12 mL
Weeks 7–8	30 u 0.30 mL	15 u 0.15 mL

Sermorelin.

Calculated volume reference

Cited protocol & reconstitution guide

Reconstitution by vial size