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5-Amino-1MQ

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Protocol01

5-Amino-1MQ

Metabolic / Weight

Vials · 10 / 50 mg

01Protocol

Vials: 10 / 50 mg
Dosing data: Lab reference — not listed

02Quick calculator

03Mechanism of action

5-Amino-1MQ is a small-molecule (not peptide) inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme involved in cellular energy metabolism. Blocking NNMT lowers its product 1-methylnicotinamide and raises intracellular NAD+.

04Study endpoints

Methylquinolinium NNMT inhibitors were selective and membrane-permeable, and reversed high-fat-diet-induced obesity measures in mice.
In diet-induced obese mice, NNMT inhibition combined with a low-fat diet normalised adiposity and weight to lean-control levels and produced a distinct gut microbiome.

05Safety & regulatory findings

Not approved by the FDA or EMA for any indication; research-grade material is not a medicine.
Evidence is limited to cell and mouse studies; no human trials are cited.

06Citations

2 references · view