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AICAR

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Protocol01

AICAR

Metabolic / Weight

Vials · 50 mg

01Protocol

Vials: 50 mg
Dosing data: Lab reference — not listed

02Quick calculator

03Mechanism of action

AICAR is a nucleoside that cells convert to an AMP mimic, activating AMP-activated protein kinase (AMPK), a sensor that drives many of exercise's effects on glucose and fat metabolism.

04Study endpoints

In sedentary mice, 4 weeks of AICAR alone induced metabolic genes and increased running endurance by 44%.
In pre-diabetic Zucker diabetic fatty rats, 8 weeks of AICAR (like exercise) prevented hyperglycaemia, improved insulin sensitivity and preserved beta-cell morphology.

05Safety & regulatory findings

Not approved by the FDA or EMA for any indication; research-grade material is not a medicine.
Listed as prohibited in sport by the World Anti-Doping Agency.
Evidence cited here is from animal studies.

06Citations

2 references · view