RESEARCH USE ONLY. Reference data for laboratory research. Not medical advice; not for human consumption.
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Protocol Single compound

AICAR

Acadesine

AMP analog precursor used as a laboratory AMPK activator in cellular energy research.

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Laboratory reference · in vitro research data

Research vial sizes
50 mg
Dosing data
Not listed — reference entry covers vial concentration only.
Storage
Powder: 2–8 °C, or −20 °C for longer storage. After mixing with BAC water: 2–8 °C, use within about 4 weeks.

Reconstitution concentrations

Concentration per BAC-water volume; 10 units = 0.1 mL on a U-100 syringe.

VialBAC watermg/mLmg per 10 u
50 mg1 mL505
50 mg2 mL252.5
50 mg3 mL16.671.667

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1 mg = 1,000 mcg
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—units

= — mL on a U-100 syringe

Concentration
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Per unit
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Doses / vial
—
Syringe
01020304050607080901000.0u
U-100 · 100 units (1 mL)2 unit per line

Research dossier · published literature summary

01

Mechanism of action

AICAR is a nucleoside that cells convert to an AMP mimic, activating AMP-activated protein kinase (AMPK), a sensor that drives many of exercise's effects on glucose and fat metabolism.

02

Observed research endpoints

  • In sedentary mice, 4 weeks of AICAR alone induced metabolic genes and increased running endurance by 44%.
  • In pre-diabetic Zucker diabetic fatty rats, 8 weeks of AICAR (like exercise) prevented hyperglycaemia, improved insulin sensitivity and preserved beta-cell morphology.

03

Regulatory & safety context

  • Not approved by the FDA or EMA for any indication; research-grade material is not a medicine.
  • Listed as prohibited in sport by the World Anti-Doping Agency.
  • Evidence cited here is from animal studies.

04

Citations

  1. Narkar VA, et al. AMPK and PPARδ agonists are exercise mimetics. Cell. 2008;134(3):405–415.2008-08Preclinical study (mouse)Read paper ↗
  2. Pold R, et al. Long-term AICAR administration and exercise prevents diabetes in ZDF rats. Diabetes. 2005;54(4):928–934.2005-04Preclinical study (rat)Read paper ↗

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