RESEARCH USE ONLY. Reference data for laboratory research. Not medical advice; not for human consumption.
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MOTS-c
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Protocol01
MOTS-c

Metabolic / Weight · Longevity

Vials · 10 / 40 mg

01Protocol

Start
5 mg
Range
5–10 mg per week
Frequency
1–2× weekly
Cycle
6–8 weeks
Vials
10 / 40 mg

02Quick calculator

Draw (100u)

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Concentration

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mg/mL

03Mechanism of action

MOTS-c is a 16-amino-acid peptide encoded in the mitochondrial 12S rRNA gene. In mice it acts mainly on skeletal muscle, inhibiting the folate cycle and purine synthesis, which activates AMPK; under metabolic stress it moves to the nucleus and regulates gene expression.

04Study endpoints

  • In mice, MOTS-c treatment prevented age-dependent and high-fat-diet-induced insulin resistance and diet-induced obesity.
  • Plasma levels of MOTS-c decline with age, according to a 2023 review.

05Safety & regulatory findings

  • Not approved by the FDA or EMA for any indication; research-grade material is not a medicine.
  • A 2023 review notes no effective clinical method of using MOTS-c has been developed; evidence is preclinical.

06Citations

2 references · view