Protocol Single compound

MOTS-c

Mitochondrial-derived peptide studied for insulin sensitivity and exercise-mimetic metabolic effects.

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Metabolic / Weight Longevity

Protocol card · research reference

Starting dose: 5 mg
Studied range: 5–10 mg per week
Frequency: 1–2× weekly
Route: Subcutaneous
Cycle: 6–8 weeks

Reconstitution reference

Storage: Powder: 2–8 °C, or −20 °C for longer storage. After mixing with BAC water: 2–8 °C, use within about 4 weeks.

MOTS-c

1–2× weekly · units to draw on a U-100 syringe for a 5 mg dose.

Vial	BAC water	mg/mL	Draw	Doses
10 mg	1 mL	10	50 u	2
10 mg	2 mL	5	100 u	2
10 mg	3 mL	3.33	150 u	2
40 mg	1 mL	40	12.5 u	8
40 mg	2 mL	20	25 u	8
40 mg	3 mL	13.33	37.5 u	8

Calculate your vial

Draw to

—units

= — mL on a U-100 syringe

Concentration: —
Per unit: —
Doses / vial: —

Syringe

U-100 · 100 units (1 mL)2 unit per line

Research dossier · published literature summary

Mechanism of action

MOTS-c is a 16-amino-acid peptide encoded in the mitochondrial 12S rRNA gene. In mice it acts mainly on skeletal muscle, inhibiting the folate cycle and purine synthesis, which activates AMPK; under metabolic stress it moves to the nucleus and regulates gene expression.

Observed research endpoints

In mice, MOTS-c treatment prevented age-dependent and high-fat-diet-induced insulin resistance and diet-induced obesity.
Plasma levels of MOTS-c decline with age, according to a 2023 review.

Regulatory & safety context

Not approved by the FDA or EMA for any indication; research-grade material is not a medicine.
A 2023 review notes no effective clinical method of using MOTS-c has been developed; evidence is preclinical.

Citations

Lee C, et al. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metab. 2015;21(3):443–454.2015-03Preclinical study (mouse)Read paper ↗
Zheng Y, et al. MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation. Front Endocrinol. 2023;14:1120533.2023Narrative reviewRead paper ↗

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Where researchers source it

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Medvinci Research

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