RESEARCH USE ONLY. Reference data for laboratory research. Not medical advice; not for human consumption.
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Semax
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Protocol01
Semax

Cognitive

Vials · 5 / 10 mg

01Protocol

Start
0.3 mg
Range
0.3–0.9 mg
Frequency
1–2× daily
Cycle
2–4 weeks
Vials
5 / 10 mg

02Quick calculator

Draw (100u)

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Concentration

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mg/mL

03Mechanism of action

Semax (Met-Glu-His-Phe-Pro-Gly-Pro) is a synthetic analog of the ACTH(4-10) fragment, with no hormonal activity on the adrenal glands. Rodent studies link it to higher brain-derived neurotrophic factor (BDNF) and its receptor TrkB in the hippocampus.

04Study endpoints

  • A single application raised BDNF and TrkB expression in the rat hippocampus.
  • The same work tied these changes to improved learning in rats.
  • Russian clinical studies have looked at it in ischemic stroke recovery.

05Safety & regulatory findings

  • Registered as a medicine in Russia; not approved by the FDA or EMA.
  • Most clinical literature is Russian-language and not independently replicated in large Western trials.

06Citations

2 references · view