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Epitalon

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Protocol01

Epitalon

Longevity

Vials · 10 / 50 mg

01Protocol

Start: 5 mg
Range: 5–10 mg
Frequency: Once daily
Cycle: 10–20 days, 1–2× per year
Vials: 10 / 50 mg

02Quick calculator

03Mechanism of action

Epitalon (Ala-Glu-Asp-Gly) is a synthetic tetrapeptide based on epithalamin, a bovine pineal extract. Reported effects include melatonin-synthesis changes, enzyme activation including telomerase, and antioxidant activity; reviewers note the mechanism is not fully established.

04Study endpoints

A 2025 review summarised about 25 years of in vitro, animal and in silico work describing geroprotective and neuroendocrine effects.
In human cell lines, epitalon extended telomere length dose-dependently in normal cells via hTERT and telomerase upregulation; in breast-cancer lines it acted through ALT activation.

05Safety & regulatory findings

Not approved by the FDA or EMA for any indication; research-grade material is not a medicine.
Most published work comes from a small number of research groups; physico-chemical and structural studies remain limited.
No large controlled human safety dataset is available.

06Citations

2 references · view