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Start

5 mg

Range

5–10 mg

Frequency

Once daily

Cycle

10–20 days, 1–2× per year

Vials

10 / 50 mg

Epitalon (Ala-Glu-Asp-Gly) is a synthetic tetrapeptide based on epithalamin, a bovine pineal extract. Reported effects include melatonin-synthesis changes, enzyme activation including telomerase, and antioxidant activity; reviewers note the mechanism is not fully established.

• A 2025 review summarised about 25 years of in vitro, animal and in silico work describing geroprotective and neuroendocrine effects.
• In human cell lines, epitalon extended telomere length dose-dependently in normal cells via hTERT and telomerase upregulation; in breast-cancer lines it acted through ALT activation.

• Not approved by the FDA or EMA for any indication; research-grade material is not a medicine.
• Most published work comes from a small number of research groups; physico-chemical and structural studies remain limited. The cited 2025 cell-line paper has a published correction replacing figures 1–3; interpretation should use the corrected version.
• No large controlled human safety dataset is available.

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