Protocol Single compound
Epitalon
Epithalon, AEDG
Synthetic tetrapeptide investigated for telomerase activity and circadian/pineal regulation.
Compare side by side →Protocol card · research reference
- Starting dose
- 5 mg
- Studied range
- 5–10 mg
- Frequency
- Once daily
- Route
- Subcutaneous
- Cycle
- 10–20 days, 1–2× per year
Reconstitution reference
Storage: Powder: 2–8 °C, or −20 °C for longer storage. After mixing with BAC water: 2–8 °C, use within about 4 weeks.
Epitalon
Once daily · units to draw on a U-100 syringe for a 5 mg dose.
| Vial | BAC water | mg/mL | Draw | Doses |
|---|---|---|---|---|
| 10 mg | 1 mL | 10 | 50 u | 2 |
| 10 mg | 2 mL | 5 | 100 u | 2 |
| 10 mg | 3 mL | 3.33 | 150 u | 2 |
| 50 mg | 1 mL | 50 | 10 u | 10 |
| 50 mg | 2 mL | 25 | 20 u | 10 |
| 50 mg | 3 mL | 16.67 | 30 u | 10 |
Calculate your vial
Draw to
—units
= — mL on a U-100 syringe
- Concentration
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- Per unit
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- Doses / vial
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Research dossier · published literature summary
01
Mechanism of action
Epitalon (Ala-Glu-Asp-Gly) is a synthetic tetrapeptide based on epithalamin, a bovine pineal extract. Reported effects include melatonin-synthesis changes, enzyme activation including telomerase, and antioxidant activity; reviewers note the mechanism is not fully established.
02
Observed research endpoints
- A 2025 review summarised about 25 years of in vitro, animal and in silico work describing geroprotective and neuroendocrine effects.
- In human cell lines, epitalon extended telomere length dose-dependently in normal cells via hTERT and telomerase upregulation; in breast-cancer lines it acted through ALT activation.
03
Regulatory & safety context
- Not approved by the FDA or EMA for any indication; research-grade material is not a medicine.
- Most published work comes from a small number of research groups; physico-chemical and structural studies remain limited.
- No large controlled human safety dataset is available.
04
Citations
- Araj SK, et al. Overview of Epitalon — Highly Bioactive Pineal Tetrapeptide with Promising Properties. Int J Mol Sci. 2025;26(6).2025-03Narrative reviewRead paper ↗
- Al-Dulaimi S, et al. Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity. Biogerontology. 2025;26(5):178.2025-09In vitro studyRead paper ↗
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