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Pick up to 3 compounds to see protocols, mechanisms, study endpoints and safety findings side by side.
Peptijournal · Semax vs Selank · https://peptijournal.com/compare?c=semax,selank · Printed
SemaxSelank
Same goal
01Protocol
Semax
- Start
- 0.3 mg
- Range
- 0.3–0.9 mg
- Frequency
- 1–2× daily
- Cycle
- 2–4 weeks
- Vials
- 5 / 10 mg
Selank
- Start
- 0.25 mg
- Range
- 0.25–0.5 mg
- Frequency
- 1–2× daily
- Cycle
- 2–4 weeks
- Vials
- 5 / 10 mg
02Quick calculator
Semax
Selank
03Mechanism of action
Semax
Semax (Met-Glu-His-Phe-Pro-Gly-Pro) is a synthetic analog of the ACTH(4-10) fragment, with no hormonal activity on the adrenal glands. Rodent studies link it to higher brain-derived neurotrophic factor (BDNF) and its receptor TrkB in the hippocampus.
Selank
Selank is a synthetic analog of tuftsin (an immune-related tetrapeptide) with an added Pro-Gly-Pro sequence for stability. It is studied for effects on enkephalin breakdown and GABAergic gene expression.
04Study endpoints
Semax
- A single application raised BDNF and TrkB expression in the rat hippocampus.
- The same work tied these changes to improved learning in rats.
- Russian clinical studies have looked at it in ischemic stroke recovery.
Selank
- In 62 patients with generalised anxiety disorder or neurasthenia, Selank's anti-anxiety effect was similar to medazepam's.
- That trial also reported anti-fatigue and stimulant-like effects, and higher blood enkephalin activity during treatment.
- Cell studies report changes in the expression of genes involved in GABA signalling.
05Safety & regulatory findings
Semax
- Registered as a medicine in Russia; not approved by the FDA or EMA.
- Most clinical literature is Russian-language and not independently replicated in large Western trials.
Selank
- Registered as a medicine in Russia; not approved by the FDA or EMA.
- The main clinical data is small and Russian-language.