Stack Stack · multiple compounds
Tirzepatide + MOTS-c
Pairing of tirzepatide with MOTS-c in separate vials, discussed for plateaus and fatigue. Tirzepatide trial data do not cover adding MOTS-c; the pair is untested.
Community opinion
Why people pair them
Discussed in clinic circles for plateaus and fatigue: tirzepatide changes appetite signaling while MOTS-c is hoped to change how cells use energy. Reports are mixed.
Example discussion (community, not a primary source)Primary sources
What the evidence shows
- SURMOUNT-1 (2,539 adults): tirzepatide weight reductions reached 20.9% at 72 weeks vs 3.1% with placebo. MOTS-c was not tested. Source
- MOTS-c metabolic evidence is from cells and mice. Source
Caveat: Tirzepatide's known safety profile does not cover adding MOTS-c; interactions are uncharacterized.
What's in it
2 ingredients in separate vials. Tap one to open its own page.
- 01
Tirzepatide
GIP / GLP-1 dual agonist
Dual GIP and GLP-1 receptor agonist studied in large clinical trials for glycemic control and weight reduction.
How it works: Tirzepatide is a single peptide that activates both the GIP and GLP-1 receptors (a 'twincretin').
Open Tirzepatide → - 02
MOTS-c
Mitochondrial-genome-encoded peptide studied in cell and rodent metabolic models, including insulin sensitivity; these experiments do not establish human exercise-replacement or treatment benefits.
How it works: MOTS-c is a 16-amino-acid peptide encoded in the mitochondrial 12S rRNA gene.
Open MOTS-c →
No schedule on file
This is a reference-only entry. The site lists its vial sizes and concentrations only — there is no published schedule for it here.
Laboratory reference · catalog presentation
- Research vial sizes
- 10 mg
- Dosing data
- Not listed — reference entry covers vial concentration only.
- Storage
- Follow the specific supplier's documented storage and stability conditions. Temperature, diluent compatibility and shelf life vary by compound and formulation; this catalog does not establish a universal post-mixing expiry.
Reconstitution concentrations
Calculated concentration by volume; 10 units = 0.1 mL on a U-100 syringe. These figures do not verify solubility, BAC-water compatibility, vial capacity or stability.
10 mg vial
1 mL water
10 mg/mL
1 mg / 10 u
2 mL water
5 mg/mL
0.5 mg / 10 u
3 mL water
3.33 mg/mL
0.333 mg / 10 u
| Vial | BAC water | mg/mL | mg per 10 u |
|---|---|---|---|
| 10 mg | 1 mL | 10 | 1 |
| 10 mg | 2 mL | 5 | 0.5 |
| 10 mg | 3 mL | 3.33 | 0.333 |
Notes
Vial size shown is a common MOTS-c listing; each compound comes in its own vial.
1
Notes
Vial size shown is a common MOTS-c listing; each compound comes in its own vial.
- Vial size shown is a common MOTS-c listing; each compound comes in its own vial.
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Research Use Only. Combination entries are laboratory reference data, not instructions for human use.Full disclaimer.