RESEARCH USE ONLY. Reference data for laboratory research. Not medical advice; not for human consumption.
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FOXO4-DRI

D-retro-inverso peptide referenced in senescent-cell (p53/FOXO4) research.

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Longevity

Laboratory reference · in vitro research data

Research vial sizes
10 mg
Dosing data
Not listed — reference entry covers vial concentration only.
Storage
Powder: 2–8 °C, or −20 °C for longer storage. After mixing with BAC water: 2–8 °C, use within about 4 weeks.

Reconstitution concentrations

Concentration per BAC-water volume; 10 units = 0.1 mL on a U-100 syringe.

VialBAC watermg/mLmg per 10 u
10 mg1 mL101
10 mg2 mL50.5
10 mg3 mL3.330.333

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mL
1 mg = 1,000 mcg
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—units

= — mL on a U-100 syringe

Concentration
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Per unit
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Doses / vial
—
Syringe
01020304050607080901000.0u
U-100 · 100 units (1 mL)2 unit per line

Research dossier · published literature summary

01

Mechanism of action

FOXO4-DRI is a modified (D-retro-inverso) peptide that disrupts the binding of FOXO4 to p53 in senescent cells, pushing p53 out of the nucleus and triggering apoptosis selectively in those cells (a senolytic).

02

Observed research endpoints

  • In mice, it neutralised doxorubicin-induced toxicity and restored fitness, fur density and kidney function in fast-ageing and naturally aged animals.
  • In keloid tissue and fibroblast models, it promoted apoptosis of senescent fibroblasts.

03

Regulatory & safety context

  • Not approved by the FDA or EMA for any indication; research-grade material is not a medicine.
  • Evidence is from cell and animal studies; no human trials are cited.

04

Citations

  1. Baar MP, et al. Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging. Cell. 2017;169(1):132–147.2017-03Preclinical study (cell, mouse)Read paper ↗
  2. Kong YX, et al. FOXO4-DRI induces keloid senescent fibroblast apoptosis by promoting nuclear exclusion of upregulated p53-serine 15 phosphorylation. Commun Biol. 2025;8:299.2025-02In vitro / ex vivo studyRead paper ↗

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