RESEARCH USE ONLY. Reference data for laboratory research. Not medical advice; not for human consumption.
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Protocol Single compound

Humanin

Mitochondrial-derived peptide referenced in cytoprotection and metabolic research.

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Longevity

Laboratory reference · in vitro research data

Research vial sizes
10 mg
Dosing data
Not listed — reference entry covers vial concentration only.
Storage
Powder: 2–8 °C, or −20 °C for longer storage. After mixing with BAC water: 2–8 °C, use within about 4 weeks.

Reconstitution concentrations

Concentration per BAC-water volume; 10 units = 0.1 mL on a U-100 syringe.

VialBAC watermg/mLmg per 10 u
10 mg1 mL101
10 mg2 mL50.5
10 mg3 mL3.330.333

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Inputs
mg
mL
1 mg = 1,000 mcg
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—units

= — mL on a U-100 syringe

Concentration
—
Per unit
—
Doses / vial
—
Syringe
01020304050607080901000.0u
U-100 · 100 units (1 mL)2 unit per line

Research dossier · published literature summary

01

Mechanism of action

Humanin is a small peptide encoded in mitochondrial DNA. It is studied as a cytoprotective signal against oxidative and metabolic stress and in the regulation of autophagy and cell senescence.

02

Observed research endpoints

  • A 2023 systematic review describes humanin as counteracting age-related conditions linked to senescence, including cardiovascular disease and diabetes, with mechanisms not fully clarified.
  • A 2025 review reports that humanin and its analogue HNG supported cell survival under metabolic and oxidative stress.

03

Regulatory & safety context

  • Not approved by the FDA or EMA for any indication; research-grade material is not a medicine.
  • Evidence is preclinical; no controlled human trials are cited.

04

Citations

  1. Coradduzza D, et al. Humanin and Its Pathophysiological Roles in Aging: A Systematic Review. Biology (Basel). 2023;12(4).2023-04Systematic reviewRead paper ↗
  2. Moin H, et al. A Review on the Potential Role of Humanin Peptide and its Analogs in the Regulation of Autophagy Pathways. Protein Pept Lett. 2025;32:161–170.2025Narrative reviewRead paper ↗

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