RESEARCH USE ONLY. Reference data for laboratory research. Not medical advice; not for human consumption.
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Protocol Single compound

IGF-1 LR3

Long R3 IGF-1

Extended-half-life IGF-1 analog referenced in cell growth and differentiation research.

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Growth Hormone

Laboratory reference · in vitro research data

Research vial sizes
1 mg
Dosing data
Not listed — reference entry covers vial concentration only.
Storage
Powder: 2–8 °C, or −20 °C for longer storage. After mixing with BAC water: 2–8 °C, use within about 4 weeks.

Reconstitution concentrations

Concentration per BAC-water volume; 10 units = 0.1 mL on a U-100 syringe.

VialBAC watermg/mLmg per 10 u
1 mg1 mL10.1
1 mg2 mL0.50.05
1 mg3 mL0.330.033

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mg
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1 mg = 1,000 mcg
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—units

= — mL on a U-100 syringe

Concentration
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Per unit
—
Doses / vial
—
Syringe
01020304050607080901000.0u
U-100 · 100 units (1 mL)2 unit per line

Research dossier · published literature summary

01

Mechanism of action

IGF-1 LR3 (Long R3 IGF-I) is a recombinant IGF-1 analogue with an extra 13-amino-acid N-terminal extension and an arginine substitution, which reduces binding to IGF-binding proteins and prolongs activity. It is widely used in cell culture.

02

Observed research endpoints

  • Recombinant LR3 IGF-1 produced in yeast showed bioactivity comparable to standard IGF-1.
  • Anti-doping analysis of a black-market product identified His-tagged Long R3 IGF-I, a form whose effects in humans have not been described.

03

Regulatory & safety context

  • Not approved by the FDA or EMA for any indication; research-grade material is not a medicine.
  • Listed as prohibited in sport by the World Anti-Doping Agency.
  • No human clinical trials of LR3 are cited; black-market products may contain unexpected variants.

04

Citations

  1. Kohler M, et al. Detection of His-tagged Long-R3-IGF-I in a black market product. Growth Horm IGF Res. 2010;20(5):386–390.2010-10Analytical case reportRead paper ↗
  2. Lu Z, et al. Recombinant expression of IGF-1 and LR3 IGF-1 fused with xylanase in Pichia pastoris. Appl Microbiol Biotechnol. 2023;107:4543–4551.2023-07Laboratory studyRead paper ↗

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