Protocol Single compound
Kisspeptin-10
Kp-10
Kisspeptin fragment referenced in hypothalamic signaling (GnRH axis) research.
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- Research vial sizes
- 10 mg
- Dosing data
- Not listed — reference entry covers vial concentration only.
- Storage
- Powder: 2–8 °C, or −20 °C for longer storage. After mixing with BAC water: 2–8 °C, use within about 4 weeks.
Reconstitution concentrations
Concentration per BAC-water volume; 10 units = 0.1 mL on a U-100 syringe.
| Vial | BAC water | mg/mL | mg per 10 u |
|---|---|---|---|
| 10 mg | 1 mL | 10 | 1 |
| 10 mg | 2 mL | 5 | 0.5 |
| 10 mg | 3 mL | 3.33 | 0.333 |
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Research dossier · published literature summary
01
Mechanism of action
Kisspeptin-10 is the shortest active fragment of kisspeptin, which activates the KISS1 receptor on GnRH neurons and drives LH, FSH and, in men, testosterone release.
02
Observed research endpoints
- In healthy men, a kisspeptin-10 infusion raised mean LH about fourfold and testosterone by roughly 45%, and increased LH pulse frequency.
- A 2026 randomized study found daily infusions sustained gonadotropin increases for 12 days, while continuous infusion for 5 days kept testosterone up but gonadotropins returned to vehicle levels.
03
Regulatory & safety context
- Not approved by the FDA or EMA for any indication; research-grade material is not a medicine.
- Studies were small physiology studies in healthy volunteers.
04
Citations
- George JT, et al. Kisspeptin-10 is a potent stimulator of LH and increases pulse frequency in men. J Clin Endocrinol Metab. 2011;96(8):E1228–E1236.2011-08Clinical physiology studyRead paper ↗
- Yeung AC, et al. Chronic subcutaneous kisspeptin-10 stimulates gonadotropin secretion for 12 days in healthy men. Eur J Endocrinol. 2026;195:206–216.2026-08Randomized controlled studyRead paper ↗
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