Protocol Single compound
Sermorelin
GHRH(1-29)
GHRH(1-29) amide referenced in growth-hormone-releasing-hormone receptor research.
Compare side by side →Compared with:Sermorelin vs Tesamorelin
Laboratory reference · in vitro research data
- Research vial sizes
- 5 mg · 10 mg
- Dosing data
- Not listed — reference entry covers vial concentration only.
- Storage
- Powder: 2–8 °C, or −20 °C for longer storage. After mixing with BAC water: 2–8 °C, use within about 4 weeks.
Reconstitution concentrations
Concentration per BAC-water volume; 10 units = 0.1 mL on a U-100 syringe.
| Vial | BAC water | mg/mL | mg per 10 u |
|---|---|---|---|
| 5 mg | 1 mL | 5 | 0.5 |
| 5 mg | 2 mL | 2.5 | 0.25 |
| 5 mg | 3 mL | 1.67 | 0.167 |
| 10 mg | 1 mL | 10 | 1 |
| 10 mg | 2 mL | 5 | 0.5 |
| 10 mg | 3 mL | 3.33 | 0.333 |
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Research dossier · published literature summary
01
Mechanism of action
Sermorelin is the first 29 amino acids of GHRH, the shortest fully active fragment. It stimulates pituitary GHRH receptors to release GH.
02
Observed research endpoints
- Used intravenously as a diagnostic test for GH deficiency, though a normal response cannot rule out hypothalamic causes.
- In some prepubertal children with idiopathic GH deficiency, height velocity increased significantly over 12 months, with limited data to 36 months.
03
Regulatory & safety context
- Was FDA-approved (Geref) but the branded product was discontinued; it is now mainly compounded or sold for research.
- Listed as prohibited in sport by the World Anti-Doping Agency.
04
Citations
- Prakash A, Goa KL. Sermorelin: a review of its use in the diagnosis and treatment of children with idiopathic growth hormone deficiency. BioDrugs. 1999;12(2):139–157.1999-08Drug reviewRead paper ↗
- Walker RF. Sermorelin: a better approach to management of adult-onset growth hormone insufficiency? Clin Interv Aging. 2006;1(4):307–308.2006EditorialRead paper ↗
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