Protocol Single compound
SLU-PP-332
ERR agonist
Estrogen-related receptor agonist referenced in exercise-mimetic metabolic research.
Compare side by side →Laboratory reference · in vitro research data
- Research vial sizes
- 5 mg · 10 mg
- Dosing data
- Not listed — reference entry covers vial concentration only.
- Storage
- Powder: 2–8 °C, or −20 °C for longer storage. After mixing with BAC water: 2–8 °C, use within about 4 weeks.
Reconstitution concentrations
Concentration per BAC-water volume; 10 units = 0.1 mL on a U-100 syringe.
| Vial | BAC water | mg/mL | mg per 10 u |
|---|---|---|---|
| 5 mg | 1 mL | 5 | 0.5 |
| 5 mg | 2 mL | 2.5 | 0.25 |
| 5 mg | 3 mL | 1.67 | 0.167 |
| 10 mg | 1 mL | 10 | 1 |
| 10 mg | 2 mL | 5 | 0.5 |
| 10 mg | 3 mL | 3.33 | 0.333 |
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Research dossier · published literature summary
01
Mechanism of action
SLU-PP-332 is a synthetic small-molecule (not peptide) agonist of the estrogen-related receptors (ERRα/β/γ), which regulate mitochondrial and fatty-acid metabolism. It is described as an exercise mimetic.
02
Observed research endpoints
- In mice it increased energy expenditure and fatty-acid oxidation, reduced fat-mass gain and improved insulin sensitivity in metabolic-syndrome models.
- In mouse pressure-overload heart failure, it improved ejection fraction, reduced fibrosis and increased survival.
03
Regulatory & safety context
- Not approved by the FDA or EMA for any indication; research-grade material is not a medicine.
- Evidence is from mouse studies; no human trials are cited.
04
Citations
- Billon C, et al. A Synthetic ERR Agonist Alleviates Metabolic Syndrome. J Pharmacol Exp Ther. 2024;388(2):232–240.2024Preclinical study (mouse)Read paper ↗
- Xu W, et al. Novel Pan-ERR Agonists Ameliorate Heart Failure Through Enhancing Cardiac Fatty Acid Metabolism and Mitochondrial Function. Circulation. 2024;149(3):227–250.2024Preclinical study (mouse)Read paper ↗
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