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Start

0.25 mg

Range

0.25–0.5 mg

Frequency

Once or twice daily

Cycle

4–8 weeks

Vials

5 / 10 mg

BPC-157 is a 15-amino-acid fragment of a protein found in gastric juice. Preclinical studies associate it with increased growth-hormone-receptor expression, angiogenesis pathways (including VEGF-related signalling) and lower inflammatory cytokines. The exact receptor target is not established.

• A 2025 systematic review found 36 studies: 35 preclinical and 1 clinical.
• Animal models showed improved functional, structural and biomechanical outcomes in muscle, tendon, ligament and bone injuries.
• The only clinical study was a small retrospective series: 7 of 12 patients with chronic knee pain reported relief for more than 6 months.

• Not FDA-approved for any use and listed as prohibited by the World Anti-Doping Agency.
• The cited human evidence does not establish systemic human pharmacokinetics; experimental clearance findings are not a validated human half-life for this research vial.
• Preclinical safety studies reported no organ toxicity, but the 2025 review found no clinical safety data.

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