Protocol Single compound
Glutathione
GSH
Endogenous tripeptide antioxidant referenced in redox and detoxification research.
Compare side by side →Laboratory reference · in vitro research data
- Research vial sizes
- 500 mg · 1000 mg
- Dosing data
- Not listed — reference entry covers vial concentration only.
- Storage
- Powder: 2–8 °C, or −20 °C for longer storage. After mixing with BAC water: 2–8 °C, use within about 4 weeks.
Reconstitution concentrations
Concentration per BAC-water volume; 10 units = 0.1 mL on a U-100 syringe.
| Vial | BAC water | mg/mL | mg per 10 u |
|---|---|---|---|
| 500 mg | 1 mL | 500 | 50 |
| 500 mg | 2 mL | 250 | 25 |
| 500 mg | 3 mL | 166.67 | 16.667 |
| 1000 mg | 1 mL | 1,000 | 100 |
| 1000 mg | 2 mL | 500 | 50 |
| 1000 mg | 3 mL | 333.33 | 33.333 |
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Research dossier · published literature summary
01
Mechanism of action
Glutathione is a tripeptide (glutamate-cysteine-glycine) that serves as the main intracellular antioxidant and is involved in detoxification and immune function.
02
Observed research endpoints
- 6-month RCT of oral glutathione: body stores rose 30–35% in red cells, plasma and lymphocytes and 260% in cheek cells in the higher arm; natural-killer cytotoxicity more than doubled at 3 months.
- 4-week RCT in 60 people: oral glutathione lowered melanin indices, significantly more than placebo at two of six skin sites.
03
Regulatory & safety context
- Sold as a dietary supplement; injectable glutathione is not FDA-approved for skin lightening.
- Both trials reported glutathione as well tolerated; long-term safety has not been established.
04
Citations
- Richie JP Jr, et al. Randomized controlled trial of oral glutathione supplementation on body stores of glutathione. Eur J Nutr. 2015;54(2):251–263.2015-03Randomized controlled trialRead paper ↗
- Arjinpathana N, Asawanonda P. Glutathione as an oral whitening agent: a randomized, double-blind, placebo-controlled study. J Dermatolog Treat. 2012;23(2):97–102.2012-04Randomized controlled trialRead paper ↗
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