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Peptijournal · KPV · https://peptijournal.com/compare?c=kpv · Impreso
KPV
Mismo objetivo
01Protocol
- Viales
- 10 mg
- Datos de dosis
- Referencia de laboratorio; no indicado
02Quick calculator
03Mechanism of action
KPV (Lys-Pro-Val) is the C-terminal tripeptide of α-MSH. It is taken up by the PepT1 transporter in gut and immune cells and inhibits NF-κB and MAP kinase inflammatory signalling.
04Study endpoints
- In mouse colitis models, oral KPV reduced intestinal inflammation and pro-inflammatory cytokine expression.
- An engineered oral KPV conjugate reached 3.8-fold higher colon levels than free KPV in colitic mice and was also anti-inflammatory in acute lung injury.
05Safety & regulatory findings
- Not approved by the FDA or EMA for any indication; research-grade material is not a medicine.
- Evidence is from cell and mouse studies; no human trials are cited.
06Citations
2 referencias · ver