Protocol Single compound
DSIP
Delta sleep-inducing peptide
Nonapeptide referenced in sleep-regulation and stress-response research.
Compare side by side →Laboratory reference · in vitro research data
- Research vial sizes
- 5 mg · 10 mg
- Dosing data
- Not listed — reference entry covers vial concentration only.
- Storage
- Powder: 2–8 °C, or −20 °C for longer storage. After mixing with BAC water: 2–8 °C, use within about 4 weeks.
Reconstitution concentrations
Concentration per BAC-water volume; 10 units = 0.1 mL on a U-100 syringe.
| Vial | BAC water | mg/mL | mg per 10 u |
|---|---|---|---|
| 5 mg | 1 mL | 5 | 0.5 |
| 5 mg | 2 mL | 2.5 | 0.25 |
| 5 mg | 3 mL | 1.67 | 0.167 |
| 10 mg | 1 mL | 10 | 1 |
| 10 mg | 2 mL | 5 | 0.5 |
| 10 mg | 3 mL | 3.33 | 0.333 |
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Research dossier · published literature summary
01
Mechanism of action
Delta sleep-inducing peptide (DSIP) is a nonapeptide first isolated from rabbit blood during induced sleep. Its receptor and physiological role have not been established.
02
Observed research endpoints
- In rats, DSIP and its analogue Deltaran activated neurons in the hippocampus, hypothalamus and thalamus.
- In a rat cerebral ischaemia model, all Deltaran-treated animals survived vs 62% of untreated animals.
03
Regulatory & safety context
- Not approved by the FDA or EMA for any indication; research-grade material is not a medicine.
- Human evidence is limited and dated; reviewers describe its function as still unclear.
04
Citations
- Kovalzon VM, Strekalova TV. Delta sleep-inducing peptide (DSIP): a still unresolved riddle. J Neurochem. 2006;97(2):303–309.2006-04Narrative reviewRead paper ↗
- Koplik EV, et al. Delta sleep-inducing peptide and Deltaran: potential approaches to antistress protection. Neurosci Behav Physiol. 2008;38(9):953–957.2008-11Preclinical study (rat)Read paper ↗
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